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KMID : 0861020100250040031
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Korea Journal of Herbology
2010 Volume.25 No. 4 p.31 ~ p.37
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Neuroprotective Effects of Agrimoniae Herba against Intrastriatal Hemorrhage in Rats
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Choi Young-Seuk
Kim Youn-Sub
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Abstract
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Objects: This study was performed in order to evaluate the effects of Agrimoniae herba (AH) ethanol extract on intrastriatal hemorrhage (ISH).
Method: ISH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type IV in Sprague-Dawley rats. AH was orally given once a day for 3 days after ISH. Hematoma volume and percentage edema were examined. Immunohistochemistry was processed for iNOS, c-Fos, MMP-9, and MMP-12 expressions in the brain sections and each immuno-labeling were calculated with image analysis.
Results: results are as follows; 1. AH reduced the hematoma volume and percentage edema of the ISH-induced rat brain. 2. AH swollen apoptotic bodies and neurons in the peri-hematoma regions of the ISH-induced rat brain. 3. AH significantly reduced c-Fos, MMP-9 and MMP-12 positive cells in the peri-hematoma regions of the ISH-induced rat brain. 4. AH swollen iNOS expressions in the peri-hematoma regions of the ISH-induced rat brain.
Conclusion: These results suggest that AH plays an anti-apoptotic neuroprotective effect through control of ISH, suppression of c-Fos, and down-regulation of MMP-9 and MMP-12 expressions in the brain tissues.
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KEYWORD
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Agrimoniae herba Hematoma, iNOS, c-Fos, MMP-9, MMP-12
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